Ontology highlight
ABSTRACT:
SUBMITTER: Swaidani S
PROVIDER: S-EPMC3666175 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Swaidani Shadi S Bulek Katarzyna K Kang Zizhen Z Gulen Muhammet Fatih MF Liu Caini C Yin Weiguo W Abbadi Amina A Aronica Mark M Li Xiaoxia X
Journal of immunology (Baltimore, Md. : 1950) 20110819 6
The cellular and molecular mechanisms driven by IL-25 and its cognate receptor IL-17RB necessary for the promotion of Th2-mediating pathogenic pulmonary inflammation remains to be defined. We have previously reported the critical role of the U-box-type E3 ubiquitin ligase Act1 (1) for the downstream signaling of the IL-17 cytokine family including the Th2-promoting cytokine IL-25 (IL-17E) (2). In this study, we report that IL-25-driven but not conventional IL-4-driven Th2 polarization and cytoki ...[more]