Ontology highlight
ABSTRACT:
SUBMITTER: Deng C
PROVIDER: S-EPMC3666258 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Deng Cheng C Reddy Pradeep P Cheng Yuan Y Luo Ching-Wei CW Hsiao Chih-Lun CL Hsueh Aaron J W AJ
Journal of cell science 20130226 Pt 9
Mammalian LGR4, 5 and 6 are seven-transmembrane receptors that are important for diverse physiological processes. These receptors are orthologous to DLGR2, a Drosophila receptor activated by the burs/pburs heterodimer important for morphogenesis. Although recent studies indicated that four R-spondin proteins are cognate ligands for LGR4, 5 and 6 receptors, several BMP antagonists in vertebrates have been postulated to be orthologous to burs and pburs. Using newly available genome sequences, we s ...[more]