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The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.


ABSTRACT: The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.

SUBMITTER: Lu W 

PROVIDER: S-EPMC3666354 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

Lu Wei W   Bushong Eric A EA   Shih Tiffany P TP   Ellisman Mark H MH   Nicoll Roger A RA  

Neuron 20130501 3


The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segreg  ...[more]

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