Ontology highlight
ABSTRACT:
SUBMITTER: Lei L
PROVIDER: S-EPMC3666718 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Lei Lei L Spradling Allan C AC
Proceedings of the National Academy of Sciences of the United States of America 20130429 21
Whether or not mammalian females generate new oocytes during adulthood from germ-line stem cells to sustain the ovarian follicle pool has recently generated controversy. We used a sensitive lineage-labeling system to determine whether stem cells are needed in female adult mice to compensate for follicular losses and to directly identify active germ-line stem cells. Primordial follicles generated during fetal life are highly stable, with a half-life during adulthood of 10 mo, and thus are suffici ...[more]