Ontology highlight
ABSTRACT:
SUBMITTER: Medina MW
PROVIDER: S-EPMC3667406 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Medina Marisa W MW Krauss Ronald M RM
Current opinion in lipidology 20130401 2
<h4>Purpose of review</h4>With the advent of whole-transcriptome sequencing, or RNA-seq, we now know that alternative splicing is a generalized phenomenon, with nearly all multiexonic genes subject to alternative splicing. In this review, we highlight recent studies examining alternative splicing as a modulator of cellular cholesterol homeostasis and as an underlying mechanism of dyslipidemia.<h4>Recent findings</h4>A number of key genes involved in cholesterol metabolism are known to undergo fu ...[more]