Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC3667494 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130101
Genome-wide protein structure prediction and structure-based function annotation have been a long-term goal in molecular biology but not yet become possible due to difficulties in modeling distant-homology targets. We developed a hybrid pipeline combining ab initio folding and template-based modeling for genome-wide structure prediction applied to the Escherichia coli genome. The pipeline was tested on 43 known sequences, where QUARK-based ab initio folding simulation generated models with TM-sc ...[more]