Ontology highlight
ABSTRACT:
SUBMITTER: Trippa L
PROVIDER: S-EPMC3667626 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Trippa Lorenzo L Rosner Gary L GL Müller Peter P
Biometrics 20110629 1
We propose optimal choice of the design parameters for random discontinuation designs (RDD) using a Bayesian decision-theoretic approach. We consider applications of RDDs to oncology phase II studies evaluating activity of cytostatic agents. The design consists of two stages. The preliminary open-label stage treats all patients with the new agent and identifies a possibly sensitive subpopulation. The subsequent second stage randomizes, treats, follows, and compares outcomes among patients in the ...[more]