Ontology highlight
ABSTRACT:
SUBMITTER: Nainggolan IM
PROVIDER: S-EPMC3667679 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nainggolan Ita M IM Harahap Alida A Ambarwati Debby D DD Liliani Rosalina V RV Megawati Dewi D Swastika Maria M Setianingsih Iswari I
Hemoglobin 20130425 3
We describe 27 cases of mild-to-severe α-thalassemia (α-thal) syndrome caused by interaction of Hb Adana [α59(E8)Gly→Asp, GGC>GAC (α2)] with deletional and nondeletional α(+)-thal mutations in Indonesian patients. Hematological profiles and clinical manifestations of all patients were assessed by routine procedures. The genotypes were generated by a multiplex-polymerase chain reaction (m-PCR), PCR-RFLP (restriction fragment length polymorphism)-based method, and DNA sequencing. The α-thal patien ...[more]