Ontology highlight
ABSTRACT:
SUBMITTER: Chang L
PROVIDER: S-EPMC3667727 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Chang Leo L Kreko Tabita T Davison Holly H Cusmano Tim T Wu Yimin Y Rothenfluh Adrian A Eaton Benjamin A BA
Molecular biology of the cell 20130417 11
Mutations in DCTN1, a component of the dynactin complex, are linked to neurodegenerative diseases characterized by a broad collection of neuropathologies. Because of the pleiotropic nature of dynactin complex function within the neuron, defining the causes of neuropathology in DCTN1 mutants has been difficult. We combined a genetic screen with cellular assays of dynactin complex function to identify genes that are critical for dynactin complex function in the nervous system. This approach identi ...[more]