Ontology highlight
ABSTRACT:
SUBMITTER: Hoze N
PROVIDER: S-EPMC3667730 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Hozé Nathanaël N Ruault Myriam M Amoruso Carlo C Taddei Angela A Holcman David D
Molecular biology of the cell 20130410 11
Spatial and temporal behavior of chromosomes and their regulatory proteins is a key control mechanism in genomic function. This is exemplified by the clustering of the 32 budding yeast telomeres that form foci in which silencing factors concentrate. To uncover the determinants of telomere distribution, we compare live-cell imaging with a stochastic model of telomere dynamics that we developed. We show that random encounters alone are inadequate to produce the clustering observed in vivo. In cont ...[more]