Ontology highlight
ABSTRACT:
SUBMITTER: Hong X
PROVIDER: S-EPMC3667825 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Hong Xiaoqi X Bu Liping L Wang Yi Y Xu Jing J Wu Jian J Huang Yufang Y Liu Jie J Suo Haiyun H Yang Lumeng L Shi Yuncen Y Lou Yi Y Sun Zhengliang Z Zhu Guoqi G Behnisch Thomas T Yu Mei M Jia Jianguo J Hai Wangxi W Meng Hongping H Liang Sheng S Huang Fang F Zou Yunzeng Y Ge Junbo J
PloS one 20130530 5
Epidemiological and clinico-pathological studies indicate a causal relationship between heart disease and Alzheimer's disease (AD). To learn whether heart disease causes an onset of AD, mice with myocardial infarction (MI) and congestive heart failure (HF) were used to test neuropsychiatric and cognitive behaviors as well as for measurements of AD related protein markers. To this end, adult mice were subjected to ligation of left anterior descending artery (LAD) and about two weeks later high-fr ...[more]