Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance.
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ABSTRACT:
SUBMITTER: Hippenmeyer S
PROVIDER: S-EPMC3668097 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance.
Hippenmeyer Simon S Johnson Randy L RL Luo Liqun L
Cell reports 20130228 3
Genomic imprinting leads to preferred expression of either the maternal or paternal alleles of a subset of genes. Imprinting is essential for mammalian development, and its deregulation causes many diseases. However, the functional relevance of imprinting at the cellular level is poorly understood for most imprinted genes. We used mosaic analysis with double markers (MADM) in mice to create uniparental disomies (UPDs) and to visualize imprinting effects with single-cell resolution. Although chro ...[more]
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