Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.
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ABSTRACT:
SUBMITTER: Ito Y
PROVIDER: S-EPMC3668506 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.
Ito Yusuke Y Shigemori Suguru S Sato Takashi T Shimazu Tomoyuki T Hatano Konomi K Otani Hajime H Kitazawa Haruki H Shimosato Takeshi T
FEBS open bio 20121112
We designed class I/II hybrid inhibitory oligodeoxynucleotides (iODNs), called iSG, and found that the sequence 5'-TTAGGG-3', which has a six-base loop head structure, and a 3'-oligo (dG)3-5 tail sequence are important for potent immunosuppressive activity. Interestingly, splenocytes isolated from ovalbumin (OVA)-immunized mice and treated with iSG3 showed suppression of not only interleukin (IL)-6, IL-12p35, IL-12p40, and interferon (IFN) γ mRNA expression, but also IL-4 and IL-13 mRNA expressi ...[more]
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