Ontology highlight
ABSTRACT:
SUBMITTER: Sen M
PROVIDER: S-EPMC3668699 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Sen Malabika M Thomas Sufi M SM Kim Seungwon S Yeh Joanne I JI Ferris Robert L RL Johnson Jonas T JT Duvvuri Umamaheswar U Lee Jessica J Sahu Nivedita N Joyce Sonali S Freilino Maria L ML Shi Haibin H Li Changyou C Ly Danith D Rapireddy Srinivas S Etter Jonathan P JP Li Pui-Kai PK Wang Lin L Chiosea Simion S Seethala Raja R RR Gooding William E WE Chen Xiaomin X Kaminski Naftali N Pandit Kusum K Johnson Daniel E DE Grandis Jennifer R JR
Cancer discovery 20120620 8
<h4>Unlabelled</h4>Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as "undruggable." We developed a decoy targeting STAT3 and conducted a phase 0 trial. Expression levels of STAT3 target genes were decreased in head and neck cancers following injection with the STAT3 decoy compared with tumors receiving saline control. Decoys have not been amenable to systemic administration due to instability. To overcome this barrier, we li ...[more]