Ontology highlight
ABSTRACT:
SUBMITTER: Shahnazari S
PROVIDER: S-EPMC3668700 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Cell host & microbe 20100730 2
Autophagy mediates the degradation of cytoplasmic contents in the lysosome and plays a significant role in immunity. Lipid second messengers have previously been implicated in the regulation of autophagy. Here, we demonstrate a signaling role for diacylglycerol (DAG) in antibacterial autophagy. DAG production was necessary for efficient autophagy of Salmonella, and its localization to bacteria-containing phagosomes preceded autophagy. The actions of phospholipase D and phosphatidic acid phosphat ...[more]