Ontology highlight
ABSTRACT:
SUBMITTER: Basso M
PROVIDER: S-EPMC3668729 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Basso Manuela M Pozzi Silvia S Tortarolo Massimo M Fiordaliso Fabio F Bisighini Cinzia C Pasetto Laura L Spaltro Gabriella G Lidonnici Dario D Gensano Francesco F Battaglia Elisa E Bendotti Caterina C Bonetto Valentina V
The Journal of biological chemistry 20130416 22
Amyotrophic lateral sclerosis is the most common motor neuron disease and is still incurable. The mechanisms leading to the selective motor neuron vulnerability are still not known. The interplay between motor neurons and astrocytes is crucial in the outcome of the disease. We show that mutant copper-zinc superoxide dismutase (SOD1) overexpression in primary astrocyte cultures is associated with decreased levels of proteins involved in secretory pathways. This is linked to a general reduction of ...[more]