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Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study.


ABSTRACT:

Background

Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers.

Methods

3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and FEV1-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference.

Results

Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 - 14.1) and mean (SD) FEV1 was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted '>5 years' showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly FEV1-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001).

Conclusion

Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline.

Trial registration

Registered at http://www.trialregister.nl with trial number ISRCTN63545820.

SUBMITTER: Mohamed Hoesein FA 

PROVIDER: S-EPMC3669040 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Publications

Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study.

Mohamed Hoesein Firdaus A A FA   Zanen Pieter P   de Jong Pim A PA   van Ginneken Bram B   Boezen H Marike HM   Groen Harry J M HJ   Oudkerk Mathijs M   de Koning Harry J HJ   Postma Dirkje S DS   Lammers Jan-Willem J JW  

Respiratory research 20130520


<h4>Background</h4>Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers.<h4>Methods</h4>3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Sm  ...[more]

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2005-01-18 | GSE1907 | GEO