Ontology highlight
ABSTRACT:
SUBMITTER: Sovik E
PROVIDER: S-EPMC3669089 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Søvik Eirik E Cornish Jennifer L JL Barron Andrew B AB
PloS one 20130531 5
Increasingly invertebrates are being used to investigate the molecular and cellular effects of drugs of abuse to explore basic mechanisms of addiction. However, in mammals the principle factors contributing to addiction are long-term adaptive responses to repeated drug use. Here we examined whether adaptive responses to cocaine are also seen in invertebrates using the honey bee model system. Repeated topical treatment with a low dose of cocaine rendered bees resistant to the deleterious motor ef ...[more]