Ontology highlight
ABSTRACT:
SUBMITTER: Guintivano J
PROVIDER: S-EPMC3669121 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Guintivano Jerry J Aryee Martin J MJ Kaminsky Zachary A ZA
Epigenetics 20130220 3
Brain cellular heterogeneity may bias cell type specific DNA methylation patterns, influencing findings in psychiatric epigenetic studies. We performed fluorescence activated cell sorting (FACS) of neuronal nuclei and Illumina HM450 DNA methylation profiling in post mortem frontal cortex of 29 major depression and 29 matched controls. We identify genomic features and ontologies enriched for cell type specific epigenetic variation. Using the top cell epigenotype specific (CETS) marks, we generate ...[more]