Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome.

ABSTRACT:

Background and objectives

Following small bowel resection (SBR), the luminal environment is altered, which contributes to clinical manifestations of short bowel syndrome (SBS) including malabsorption, mucosal inflammation and bacterial overgrowth. However, the impact of SBR on the colon has not been well-defined. The aims of this study were to characterize the colonic microbiota following SBR and to assess the impact of SBR on mucosal inflammation in the colon.

Results

Analysis of the colonic microbiota demonstrated that there was a significant level of dysbiosis both two and six weeks post-SBR, particularly in the phylum Firmicutes, coupled with a decrease in overall bacterial diversity in the colon. This decrease in diversity was associated with an increase in colonic infl

SUBMITTER: Lapthorne S 

PROVIDER: S-EPMC3669166 | biostudies-literature | 2013 May-Jun

REPOSITORIES: biostudies-literature