Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC3669230 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Li Guangnan G Fang Li L Fernández Gloria G Pleasure Samuel J SJ
Neuron 20130502 4
Adult neurogenesis represents a unique form of plasticity in the dentate gyrus requiring the presence of long-lived neural stem cells (LL-NSCs). However, the embryonic origin of these LL-NSCs remains unclear. The prevailing model assumes that the dentate neuroepithelium throughout the longitudinal axis of the hippocampus generates both the LL-NSCs and embryonically produced granule neurons. Here we show that the NSCs initially originate from the ventral hippocampus during late gestation and then ...[more]