Ontology highlight
ABSTRACT:
SUBMITTER: van de Waterbeemd B
PROVIDER: S-EPMC3669287 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
van de Waterbeemd Bas B Zomer Gijsbert G Kaaijk Patricia P Ruiterkamp Nicole N Wijffels René H RH van den Dobbelsteen Germie P J M GP van der Pol Leo A LA
PloS one 20130531 5
An improved detergent-free process has been developed to produce vaccine based on native outer membrane vesicles (NOMV) against Neisseria meningitidis serogroup B. Performance was evaluated with the NonaMen vaccine concept, which provides broad coverage based on nine distinct PorA antigens. Scalable aseptic equipment was implemented, replacing undesirable steps like ultracentrifugation, inactivation with phenol, and the use of preservatives. The resulting process is more consistent and gives a h ...[more]