Dataset Information
High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
Ontology highlight
ABSTRACT: Objective
To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province.Materials and methods
Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 gag, partial pol, vpr-env fragment, half-genome, or near-full-length sequences were analyzed to determine the HIV-1 genotypes of each subject. Results were compared with findings from past studies of IDUs in Dehong and in neighboring Myanmar.Results
We observed a high prevalence of B'/C recombinants (82.4%) among IDUs in Dehong, the structural profiles of which do not match those previously reported in Dehong or in Myanmar. Furthermore, statistically significant differences in geographical and temporal distributions of HIV-1 genotypes were characterized by a predominance of HIV-1 B'/C recombinant forms among older subjects(p?=?0.034), subjects from Longchuan district (p?=?0.022), and subjects diagnosed between 2000 and 2004 (p?=?0.004).Conclusions
The increasing prevalence of multiple, new B'/C recombinant forms suggest that HIV-1 intersubtype recombination is substantial and ongoing in western Yunnan. This reflects the high-risk behavior of IDUs in this region and argues the need for stronger monitoring and prevention measures in Dehong and other high-prevalence areas around China.
SUBMITTER: Han X
PROVIDER: S-EPMC3669332 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
PloS one 20130531 5
<h4>Objective</h4>To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province.<h4>Materials and methods</h4>Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 gag, partial pol, vpr-env fragment, half-genome, or near-full-length sequences were analyze ...[more]