Cognitive decline in older persons initiating anticholinergic medications.

ABSTRACT:

Background

This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.

Methods

Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.

Results

Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE?=?0.005), -0.081(SE?=?0.011), and -0.096 (SE?=?0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference?=?-0.034 z-score units/year, SE?=?0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p?=?0.1).

Conclusions

Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.

SUBMITTER: Shah RC 

PROVIDER: S-EPMC3669362 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature