Fibrous dysplasia and fibroblast growth factor-23 regulation.
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ABSTRACT:
SUBMITTER: Boyce AM
PROVIDER: S-EPMC3669677 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Fibrous dysplasia and fibroblast growth factor-23 regulation.
Boyce Alison M AM Bhattacharyya Nisan N Collins Michael T MT
Current osteoporosis reports 20130601 2
Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gsα that result in elevations in cAMP. A feature of FD is elevated blood levels of the bone cell-derived phosphaturic hormone, fibroblast growth factor-23 (FGF23). FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. An essential step in the production of biologically active FGF23 is glycosylation by the UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminy ...[more]
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