Classic selective sweeps were rare in recent human evolution.
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ABSTRACT:
SUBMITTER: Hernandez RD
PROVIDER: S-EPMC3669691 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Classic selective sweeps were rare in recent human evolution.
Hernandez Ryan D RD Kelley Joanna L JL Elyashiv Eyal E Melton S Cord SC Auton Adam A McVean Gilean G Sella Guy G Przeworski Molly M
Science (New York, N.Y.) 20110201 6019
Efforts to identify the genetic basis of human adaptations from polymorphism data have sought footprints of "classic selective sweeps" (in which a beneficial mutation arises and rapidly fixes in the population).Yet it remains unknown whether this form of natural selection was common in our evolution. We examined the evidence for classic sweeps in resequencing data from 179 human genomes. As expected under a recurrent-sweep model, we found that diversity levels decrease near exons and conserved n ...[more]
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