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Chromatin insulators: linking genome organization to cellular function.

ABSTRACT: A growing body of evidence suggests that insulators have a primary role in orchestrating the topological arrangement of higher-order chromatin architecture. Insulator-mediated long-range interactions can influence the epigenetic status of the genome and, in certain contexts, may have important effects on gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome.

SUBMITTER: Phillips-Cremins JE

PROVIDER: S-EPMC3670141 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Chromatin insulators: linking genome organization to cellular function.

Phillips-Cremins Jennifer E JE Corces Victor G VG

Molecular cell 20130501 4

A growing body of evidence suggests that insulators have a primary role in orchestrating the topological arrangement of higher-order chromatin architecture. Insulator-mediated long-range interactions can influence the epigenetic status of the genome and, in certain contexts, may have important effects on gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome. ...[more]

PMID: 23706817

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