Ontology highlight
ABSTRACT:
SUBMITTER: Garmy-Susini B
PROVIDER: S-EPMC3670313 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Garmy-Susini Barbara B Avraamides Christie J CJ Desgrosellier Jay S JS Schmid Michael C MC Foubert Philippe P Ellies Lesley G LG Lowy Andrew M AM Blair Sarah L SL Vandenberg Scott R SR Datnow Brian B Wang Huan-You HY Cheresh David A DA Varner Judith J
Proceedings of the National Academy of Sciences of the United States of America 20130513 22
Lymph nodes are initial sites of tumor metastasis, yet whether the lymph node microenvironment actively promotes tumor metastasis remains unknown. We show here that VEGF-C/PI3Kα-driven remodeling of lymph nodes promotes tumor metastasis by activating integrin α4β1 on lymph node lymphatic endothelium. Activated integrin α4β1 promotes expansion of the lymphatic endothelium in lymph nodes and serves as an adhesive ligand that captures vascular cell adhesion molecule 1 (VCAM-1)(+) metastatic tumor c ...[more]