Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3670356 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.
Li Yan Y Stam Floor J FJ Aimone James B JB Goulding Martyn M Callaway Edward M EM Gage Fred H FH
Proceedings of the National Academy of Sciences of the United States of America 20130513 22
New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induc ...[more]
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