Ontology highlight
ABSTRACT:
SUBMITTER: Price JC
PROVIDER: S-EPMC3670891 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Price Jessica C JC Pollock Lana M LM Rudd Meghan L ML Fogoros Sarah K SK Mohamed Hassan H Hanigan Christin L CL Le Gallo Matthieu M Zhang Suiyuan S Cruz Pedro P Cherukuri Praveen F PF Hansen Nancy F NF McManus Kirk J KJ Godwin Andrew K AK Sgroi Dennis C DC Mullikin James C JC Merino Maria J MJ Hieter Philip P Bell Daphne W DW
PloS one 20130603 6
Most endometrial cancers can be classified histologically as endometrioid, serous, or clear cell. Non-endometrioid endometrial cancers (NEECs; serous and clear cell) are the most clinically aggressive of the three major histotypes and are characterized by aneuploidy, a feature of chromosome instability. The genetic alterations that underlie chromosome instability in endometrial cancer are poorly understood. In the present study, we used Sanger sequencing to search for nucleotide variants in the ...[more]