Ontology highlight
ABSTRACT:
SUBMITTER: Lanigan RM
PROVIDER: S-EPMC3671500 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20130416 9
B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using commercially available resins, with no need for aqueous workup or chromatography. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemizati ...[more]