Dataset Information

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

ABSTRACT:

Objective

To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD).

Methods

In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and 2) MDD status (depressed; partial remission; full remission) in 172 available participants (85% of the original cohort). Regression analyses were performed to examine the effects of treatment group assignment, as well as follow-up antidepressant medication use and self-reported exercise (Godin Leisure-Time Exercise Questionnaire), on the two outcomes.

Results

In the original study, patients receiving exercise achieved similar benefits compared with those receiving sertraline. At the time of the 1-year follow-up, rates of MDD remission increased from 46% at post treatment to 66% for participants available for follow-up. Neither initial treatment group assignment nor antidepressant medication use during the follow-up period were significant predictors of MDD remission at 1 year. However, regular exercise during the follow-up period predicted both Hamilton Depression Rating Scale scores and MDD diagnosis at 1 year. This relationship was curvilinear, with the association concentrated between 0 minute and 180 minutes of weekly exercise.

Conclusion

The effects of aerobic exercise on MDD remission seem to be similar to sertraline after 4 months of treatment; exercise during the follow-up period seems to extend the short-term benefits of exercise and may augment the benefits of antidepressant use.

Trial registration

clinicaltrials.gov Identifier: NCT00331305.

SUBMITTER: Hoffman BM

PROVIDER: S-EPMC3671874 | biostudies-literature | 2011 Feb-Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Hoffman Benson M BM Babyak Michael A MA Craighead W Edward WE Sherwood Andrew A Doraiswamy P Murali PM Coons Michael J MJ Blumenthal James A JA

Psychosomatic medicine 20101210 2

<h4>Objective</h4>To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD).<h4>Methods</h4>In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and ...[more]

PMID: 21148807

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Dataset Information

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Objective

Methods

Results

Conclusion

Trial registration

Publications

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Similar Datasets

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