Ontology highlight
ABSTRACT:
SUBMITTER: Gustavsson M
PROVIDER: S-EPMC3671886 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Gustavsson Martin M Traaseth Nathaniel J NJ Veglia Gianluigi G
Biochimica et biophysica acta 20110803 2
In this paper, we analyzed the ground and excited states of phospholamban (PLN), a membrane protein that regulates sarcoplasmic reticulum calcium ATPase (SERCA), in different membrane mimetic environments. Previously, we proposed that the conformational equilibria of PLN are central to SERCA regulation. Here, we show that these equilibria detected in micelles and bicelles are also present in native sarcoplasmic reticulum lipid membranes as probed by MAS solid-state NMR. Importantly, we found tha ...[more]