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Vitamin B?? derivatives as activators of soluble guanylyl cyclase.

ABSTRACT: Various newly prepared and previously known vitamin B?? derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

SUBMITTER: o Proinsias K 

PROVIDER: S-EPMC3671888 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Vitamin B₁₂ derivatives as activators of soluble guanylyl cyclase.

ó Proinsias Keith K   Gryko Daniel T DT   Hisaeda Yoshio Y   Martin Emil E   Sessler Jonathan L JL   Gryko Dorota D  

Journal of medicinal chemistry 20121005 20

Various newly prepared and previously known vitamin B₁₂ derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions. ...[more]

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