Ontology highlight
ABSTRACT:
SUBMITTER: Liu BQ
PROVIDER: S-EPMC3672299 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Liu Bao-Qin BQ Du Zhen-Xian ZX Zong Zhi-Hong ZH Li Chao C Li Ning N Zhang Qiang Q Kong De-Hui DH Wang Hua-Qin HQ
Autophagy 20130410 6
Emerging lines of evidence have shown that blockade of ubiquitin-proteasome system (UPS) activates autophagy. The molecular players that regulate the relationship between them remain to be elucidated. Bcl-2 associated athanogene 3 (BAG3) is a member of the BAG co-chaperone family that regulates the ATPase activity of heat shock protein 70 (HSP70) chaperone family. Studies on BAG3 have demonstrated that it plays multiple roles in physiological and pathological processes, including antiapoptotic a ...[more]