Ontology highlight
ABSTRACT:
SUBMITTER: Seiradake E
PROVIDER: S-EPMC3672960 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Seiradake Elena E Harlos Karl K Sutton Geoff G Aricescu A Radu AR Jones E Yvonne EY
Nature structural & molecular biology 20100314 4
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD). Unliganded eEphA2 forms linear arrays of staggered parallel receptors involving two patches of residues conserved across A-class Ephs. eEphA2-ephrinA5 RB ...[more]