Ontology highlight
ABSTRACT:
SUBMITTER: Fischer MT
PROVIDER: S-EPMC3673462 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Fischer Marie Therese MT Wimmer Isabella I Höftberger Romana R Gerlach Susanna S Haider Lukas L Zrzavy Tobias T Hametner Simon S Mahad Don D Binder Christoph J CJ Krumbholz Markus M Bauer Jan J Bradl Monika M Lassmann Hans H
Brain : a journal of neurology 20130517 Pt 6
Cortical lesions constitute an important part of multiple sclerosis pathology. Although inflammation appears to play a role in their formation, the mechanisms leading to demyelination and neurodegeneration are poorly understood. We aimed to identify some of these mechanisms by combining gene expression studies with neuropathological analysis. In our study, we showed that the combination of inflammation, plaque-like primary demyelination and neurodegeneration in the cortex is specific for multipl ...[more]