Ontology highlight
ABSTRACT:
SUBMITTER: Van de Walle I
PROVIDER: S-EPMC3673751 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Van de Walle Inge I De Smet Greet G Gärtner Martina M De Smedt Magda M Waegemans Els E Vandekerckhove Bart B Leclercq Georges G Plum Jean J Aster Jon C JC Bernstein Irwin D ID Guidos Cynthia J CJ Kyewski Bruno B Taghon Tom T
Blood 20110303 17
Notch signaling critically mediates various hematopoietic lineage decisions and is induced in mammals by Notch ligands that are classified into 2 families, Delta-like (Delta-like-1, -3 and -4) and Jagged (Jagged1 and Jagged2), based on structural homology with both Drosophila ligands Delta and Serrate, respectively. Because the functional differences between mammalian Notch ligands were still unclear, we have investigated their influence on early human hematopoiesis and show that Jagged2 affects ...[more]