Attenuating myocardial ischemia by targeting A2B adenosine receptors.
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ABSTRACT:
SUBMITTER: Eltzschig HK
PROVIDER: S-EPMC3674126 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Attenuating myocardial ischemia by targeting A2B adenosine receptors.
Eltzschig Holger K HK Bonney Stephanie K SK Eckle Tobias T
Trends in molecular medicine 20130326 6
Myocardial ischemia is associated with profound tissue hypoxia due to an imbalance in oxygen supply and demand, and studies of hypoxia-elicited adaptive responses during myocardial ischemia revealed a cardioprotective role for the signaling molecule adenosine. In ischemic human hearts, the A2B adenosine receptor (ADORA2B) is selectively induced. Functional studies in genetic models show that ADORA2B signaling attenuates myocardial infarction by adapting metabolism towards more oxygen efficient u ...[more]
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