Collagen prolyl hydroxylases are essential for breast cancer metastasis.
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ABSTRACT:
SUBMITTER: Gilkes DM
PROVIDER: S-EPMC3674184 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
RETRACTED: Collagen prolyl hydroxylases are essential for breast cancer metastasis.
Gilkes Daniele M DM Chaturvedi Pallavi P Bajpai Saumendra S Wong Carmen C CC Wei Hong H Pitcairn Stephen S Hubbi Maimon E ME Wirtz Denis D Semenza Gregg L GL
Cancer research 20130328 11
The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis of human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and metastasis to lymph node ...[more]
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