Ontology highlight
ABSTRACT:
SUBMITTER: Martin DP
PROVIDER: S-EPMC3674230 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Martin David P DP Cohen Seth M SM
Chemical communications (Cambridge, England) 20120424 43
A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors. ...[more]