Unknown

Dataset Information

0

Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.


ABSTRACT: A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.

SUBMITTER: Martin DP 

PROVIDER: S-EPMC3674230 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.

Martin David P DP   Cohen Seth M SM  

Chemical communications (Cambridge, England) 20120424 43


A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors. ...[more]

Similar Datasets

| S-EPMC6404860 | biostudies-literature
| S-EPMC4964523 | biostudies-literature
| S-EPMC8126098 | biostudies-literature
| S-EPMC6273245 | biostudies-literature
| S-EPMC7602163 | biostudies-literature
| S-EPMC4505086 | biostudies-literature
| S-EPMC7236246 | biostudies-literature
| S-EPMC7215574 | biostudies-literature
| S-EPMC7717713 | biostudies-literature
| S-EPMC10096498 | biostudies-literature