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Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.

ABSTRACT: A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.

SUBMITTER: Martin DP 

PROVIDER: S-EPMC3674230 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.

Martin David P DP   Cohen Seth M SM  

Chemical communications (Cambridge, England) 20120424 43

A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors. ...[more]

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