Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC3674236 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Singh Shailendra Kumar SK Maeda Kazuhiko K Eid Mohammed Mansour Abbas MM Almofty Sarah Ameen SA Ono Masaya M Pham Phuong P Goodman Myron F MF Sakaguchi Nobuo N
Nature communications 20130101
Somatic hypermutation in B cells is initiated by activation-induced cytidine deaminase-catalyzed C→U deamination at immunoglobulin variable regions. Here we investigate the role of the germinal centre-associated nuclear protein (GANP) in enhancing the access of activation-induced cytidine deaminase (AID) to immunoglobulin variable regions. We show that the nuclear export factor GANP is involved in chromatin modification at rearranged immunoglobulin variable loci, and its activity requires a hist ...[more]