Ontology highlight
ABSTRACT:
SUBMITTER: Li MM
PROVIDER: S-EPMC3674258 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Ming-Ming MM Nilsen Anja A Shi Yue Y Fusser Markus M Ding Yue-He YH Fu Ye Y Liu Bo B Niu Yamei Y Wu Yong-Sheng YS Huang Chun-Min CM Olofsson Maria M Jin Kang-Xuan KX Lv Ying Y Xu Xing-Zhi XZ He Chuan C Dong Meng-Qiu MQ Rendtlew Danielsen Jannie M JM Klungland Arne A Yang Yun-Gui YG
Nature communications 20130101
Regulation of actomyosin dynamics by post-transcriptional modifications in cytoplasmic actin is still poorly understood. Here we demonstrate that dioxygenase ALKBH4-mediated demethylation of a monomethylated site in actin (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes such as cytokinesis and cell migration. ALKBH4-deficient cells display elevated K84me1 levels. Non-muscle myosin II only interacts with unmethylated actin and its proper recruitment to and interactio ...[more]