Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC3674428 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhao Bao B Wang Yanzhong Y Wu Bo B Liu Shan S Wu Erjie E Fan HongXia H Gui MingMing M Chen Lizhao L Li Changfei C Ju Ying Y Zhang Wei W Meng Songdong S
Scientific reports 20130101
A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens. Given the striking similarity of antigen expression patterns between cancer and embryonic tissues, we defined a prototype strategy of using placenta-derived heat shock protein gp96, which induces prophylactic anti-tumor T cell responses. Immunization with placental gp96 provided partial protection and long-term (at least 3 months) anti-tumor immunity against growth of transplantable me ...[more]