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Placenta-derived gp96 as a multivalent prophylactic cancer vaccine.


ABSTRACT: A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens. Given the striking similarity of antigen expression patterns between cancer and embryonic tissues, we defined a prototype strategy of using placenta-derived heat shock protein gp96, which induces prophylactic anti-tumor T cell responses. Immunization with placental gp96 provided partial protection and long-term (at least 3 months) anti-tumor immunity against growth of transplantable melanoma or breast tumors in mice, elicited total protection against 7, 12-dimethylbenz(a)-anthracene (DMBA)-induced mammary tumors in rats, and significantly reduced the occurrence and growth of autochthonous breast tumors in HER2 transgenic mice. Placental gp96 activated HER2- and MUC1-specific T cell responses through binding to tumor-associated antigens. Our results reveal the novel immunogenicity of placental gp96 and its potential use as a multivalent cancer vaccine.

SUBMITTER: Zhao B 

PROVIDER: S-EPMC3674428 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Placenta-derived gp96 as a multivalent prophylactic cancer vaccine.

Zhao Bao B   Wang Yanzhong Y   Wu Bo B   Liu Shan S   Wu Erjie E   Fan HongXia H   Gui MingMing M   Chen Lizhao L   Li Changfei C   Ju Ying Y   Zhang Wei W   Meng Songdong S  

Scientific reports 20130101


A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens. Given the striking similarity of antigen expression patterns between cancer and embryonic tissues, we defined a prototype strategy of using placenta-derived heat shock protein gp96, which induces prophylactic anti-tumor T cell responses. Immunization with placental gp96 provided partial protection and long-term (at least 3 months) anti-tumor immunity against growth of transplantable me  ...[more]

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