Unknown

Dataset Information

0

Ictal high-frequency oscillations at 80-200 Hz coupled with delta phase in epileptic spasms.


ABSTRACT: Previous studies of epileptic spasms reported that ictal events were associated with high-frequency oscillations (HFOs) or delta waves involving widespread regions. We determined whether ictal HFOs at 80-200 Hz were coupled with a phase of slow-wave, whether ictal slow-waves were diffusely or locally synchronous signals, and whether the mode of coupling between HFOs and slow-wave phases differed between ictal and interictal states. We studied 11 children who underwent extraoperative electrocorticography (ECoG) recording. The phases and amplitudes of slow-waves were measured at the peak of ictal and interictal HFOs in the seizure-onset sites. Ictal HFOs were locked tightly to the phase of slow-wave at ?1 Hz. Ictal slow-waves propagated from the seizure-onset site to other regions. In contrast, interictal HFOs in the seizure-onset site were loosely locked to the phase of slow-wave at ?1 Hz but tightly to that of ?3-Hz. Ictal slow-waves coupled with HFOs can be explained as near-field and locally synchronized potentials generated by the neocortex rather than far-field potentials generated by subcortical structures. Ictal slow-waves in epileptic spasms may be generated by a mechanism different from what generates interictal HFOs-slow-wave complexes.

SUBMITTER: Nariai H 

PROVIDER: S-EPMC3674760 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Ictal high-frequency oscillations at 80-200 Hz coupled with delta phase in epileptic spasms.

Nariai Hiroki H   Matsuzaki Naoyuki N   Juhász Csaba C   Nagasawa Tetsuro T   Sood Sandeep S   Chugani Harry T HT   Asano Eishi E  

Epilepsia 20110913 10


Previous studies of epileptic spasms reported that ictal events were associated with high-frequency oscillations (HFOs) or delta waves involving widespread regions. We determined whether ictal HFOs at 80-200 Hz were coupled with a phase of slow-wave, whether ictal slow-waves were diffusely or locally synchronous signals, and whether the mode of coupling between HFOs and slow-wave phases differed between ictal and interictal states. We studied 11 children who underwent extraoperative electrocorti  ...[more]

Similar Datasets

| S-EPMC3051422 | biostudies-literature
| S-EPMC3764053 | biostudies-literature
| S-EPMC3775780 | biostudies-literature
| S-EPMC3774655 | biostudies-literature
| S-EPMC6930281 | biostudies-literature
| S-EPMC9283246 | biostudies-literature
| S-EPMC8886099 | biostudies-literature
| S-EPMC7793812 | biostudies-literature
| S-EPMC3771929 | biostudies-literature
| S-EPMC4302232 | biostudies-literature