Ontology highlight
ABSTRACT:
SUBMITTER: Mehrotra S
PROVIDER: S-EPMC3674773 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Mehrotra Shikhar S Al-Khami Amir A AA Klarquist Jared J Husain Shahid S Naga Osama O Eby Jonathan M JM Murali Anuradha K AK Lyons Gretchen E GE Li Mingli M Spivey Natali D ND Norell Håkan H Martins da Palma Telma T Onicescu Georgiana G Diaz-Montero C Marcela CM Garrett-Mayer Elizabeth E Cole David J DJ Le Poole I Caroline IC Nishimura Michael I MI
Journal of immunology (Baltimore, Md. : 1950) 20120713 4
Recent advancements in T cell immunotherapy suggest that T cells engineered with high-affinity TCR can offer better tumor regression. However, whether a high-affinity TCR alone is sufficient to control tumor growth, or the T cell subset bearing the TCR is also important remains unclear. Using the human tyrosinase epitope-reactive, CD8-independent, high-affinity TCR isolated from MHC class I-restricted CD4(+) T cells obtained from tumor-infiltrating lymphocytes (TIL) of a metastatic melanoma pati ...[more]