Ontology highlight
ABSTRACT:
SUBMITTER: Cousminer DL
PROVIDER: S-EPMC3674797 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cousminer Diana L DL Berry Diane J DJ Timpson Nicholas J NJ Ang Wei W Thiering Elisabeth E Byrne Enda M EM Taal H Rob HR Huikari Ville V Bradfield Jonathan P JP Kerkhof Marjan M Groen-Blokhuis Maria M MM Kreiner-Møller Eskil E Marinelli Marcella M Holst Claus C Leinonen Jaakko T JT Perry John R B JR Surakka Ida I Pietiläinen Olli O Kettunen Johannes J Anttila Verneri V Kaakinen Marika M Sovio Ulla U Pouta Anneli A Das Shikta S Lagou Vasiliki V Power Chris C Prokopenko Inga I Evans David M DM Kemp John P JP St Pourcain Beate B Ring Susan S Palotie Aarno A Kajantie Eero E Osmond Clive C Lehtimäki Terho T Viikari Jorma S JS Kähönen Mika M Warrington Nicole M NM Lye Stephen J SJ Palmer Lyle J LJ Tiesler Carla M T CM Flexeder Claudia C Montgomery Grant W GW Medland Sarah E SE Hofman Albert A Hakonarson Hakon H Guxens Mònica M Bartels Meike M Salomaa Veikko V Murabito Joanne M JM Kaprio Jaakko J Sørensen Thorkild I A TI Ballester Ferran F Bisgaard Hans H Boomsma Dorret I DI Koppelman Gerard H GH Grant Struan F A SF Jaddoe Vincent W V VW Martin Nicholas G NG Heinrich Joachim J Pennell Craig E CE Raitakari Olli T OT Eriksson Johan G JG Smith George Davey GD Hyppönen Elina E Järvelin Marjo-Riitta MR McCarthy Mark I MI Ripatti Samuli S Widén Elisabeth E
Human molecular genetics 20130227 13
The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared und ...[more]