Ontology highlight
ABSTRACT:
SUBMITTER: Shi S
PROVIDER: S-EPMC3674857 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Shi SongTing S Hoogaars Willem M H WM de Gorter David J J DJ van Heiningen Sandra H SH Lin Herbert Y HY Hong Charles C CC Kemaladewi Dwi U DU Aartsma-Rus Annemieke A ten Dijke Peter P 't Hoen Peter A C PA
Neurobiology of disease 20101016 2
Duchenne Muscular Dystrophy (DMD) is an X-linked lethal muscle wasting disease characterized by muscle fiber degeneration and necrosis. The progressive pathology of DMD can be explained by an insufficient regenerative response resulting in fibrosis and adipose tissue formation. BMPs are known to inhibit myogenic differentiation and in a previous study we found an increased expression of a BMP family member BMP4 in DMD myoblasts. The aim of the current study was therefore to investigate whether i ...[more]