Structural biology of the PCI-protein fold.
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ABSTRACT:
SUBMITTER: Ellisdon AM
PROVIDER: S-EPMC3675071 | biostudies-literature | 2012 Jul-Aug
REPOSITORIES: biostudies-literature
Publications
Structural biology of the PCI-protein fold.
Ellisdon Andrew M AM Stewart Murray M
Bioarchitecture 20120701 4
The PCI fold is based on a stack of α-helices topped with a winged-helix domain and is found in a range of proteins that form central parts of large complexes such as the proteasome lid, the COP9 signalosome, elongation factor eIF3, and the TREX-2 complex. Recent structural determinations have given intriguing insight into how these folds function both to facilitate the generation of larger proteinaceous assembles and also to interact functionally with nucleic acids. ...[more]
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