Ontology highlight
ABSTRACT:
SUBMITTER: Sleiman D
PROVIDER: S-EPMC3675109 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130606 6
The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) requires the opening of the three-dimensional structure of the primer tRNA(Lys) 3 for its annealing to the viral RNA at the primer binding site (PBS). Despite the fact that the result of this rearrangement is thermodynamically more stable, there is a high-energy barrier that requires the chaperoning activity of the viral nucleocapsid protein. In addition to the nucleotide complementarity to the PBS, severa ...[more]